Requirements for tube sheets in biopharmaceutical equipment

Materials and Cleanliness: Tube sheets in biopharmaceutical equipment must be made of 316L stainless steel to ensure corrosion resistance and prevent particle release. The surface must be highly polished to prevent material adhesion, facilitate cleaning and disinfection, prevent microbial contamination, and comply with GMP cleanroom standards.

Structural Design: The connection between the tube sheet and heat exchange tubes must be reliably sealed, minimizing dead spaces and crevices. The design should be simple to facilitate in-line cleaning and sterilization, ensuring the continuity and safety of pharmaceutical production and reducing the risk of cross-contamination.

Precision and Maintenance: Processing precision directly affects assembly sealing performance, requiring strict tolerance control. Regular maintenance and inspection of surface quality are necessary to ensure long-term stable operation of the equipment and meet the stringent requirements for reliability and compliance in biopharmaceutical manufacturing.